Autosomal translocation associated with premature ovarian failure

Autosomal translocation associated with premature ovarian failure.

EDITOR—Although the average age of menarche has decreased over the last century, the mean age of menopause appears to be invariant with time and race and occurs at approximately 50 years. The loss of functional follicles occurring in women under the age of 40 is defined as premature ovarian failure. It occurs in about 1-2% of women, in some as early as their teens. Before the onset of premature...

A de novo Reciprocal X; 9 Translocation in A Patient with Premature Ovarian Failure

A Consanguinity Related Autosomal Translocation which Leads to Premature Ovarian Failure.

The premature ovarian failures with underlying chromosomal abnormalities are normally X-linked, although their associations with the autosomal and the Robertsonian translocations are also possible. Here, we are reporting a case of premature ovarian failure which was associated with a translocation between the long arm of chromosome 7 at q11.23 and the short arm of chromosome 5 at p15.3. The pro...

INHA promoter polymorphisms are associated with premature ovarian failure.

Inhibin is an important glycoprotein that is involved in folliculogenesis. INHA, the gene encoding the inhibin alpha subunit, was recently proposed as a candidate for premature ovarian failure (POF), a syndrome that leads to the cessation of ovarian function under the age of 40 years. 70 POF patients and 70 controls were screened for the previously identified INHA -16C>T transition mutation. Th...

a de novo reciprocal x; 9 translocation in a patient with premature ovarian failure

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